Tier list
Potion Tier List
All 63 Slay the Spire 2 potions graded S–D by raw combat impact and flexibility. Hover any potion for the reasoning.
Updated for Early Access patch 0.104.0· Updated 2026-06-06
Best potions: Blood Potion, Entropic Brew, Fairy in a Bottle, Fire Potion. These are the picks worth saving for boss turns.
S
Blood PotionBlood Potion · Tier SHeals 20% of Max HP — premium between-fight or in-fight sustain that any deck wants.
Entropic BrewEntropic Brew · Tier SRefills every empty potion slot for free, the best value engine when paired with potion-economy relics.
Fairy in a BottleFairy in a Bottle · Tier SAuto-revives you to 30% HP on a lethal hit, turning a fatal mistake into a survivable fight.
Fire PotionFire Potion · Tier S20 flat damage on demand reliably finishes an enemy or burns down an elite at any point in the run.A
Block PotionBlock Potion · Tier A12 instant Block is a clean panic button against any big incoming hit.
Bone BrewBone Brew · Tier ASummon 15 floods the Necrobinder board instantly for big Osty payoffs.
Bottled PotentialBottled Potential · Tier AA full reshuffle and 5-card draw is a powerful reset and combo enabler.
Cosmic ConcoctionCosmic Concoction · Tier AThree upgraded Colorless cards feed the Regent's Colorless engine with immediate value.
Cunning PotionCunning Potion · Tier AThree upgraded Shivs is a free burst and Shiv-payoff trigger for the Silent.
Distilled ChaosDistilled Chaos · Tier APlays the top 3 cards free, explosive in a deck full of cheap value cards.
DuplicatorDuplicator · Tier AReplaying your next card doubles a key Power or big attack for huge tempo.
Energy PotionEnergy Potion · Tier AExtra energy enables a combo or burst turn exactly when you need it most.
Essence of DarknessEssence of Darkness · Tier AChannels a Dark per Orb Slot, a board-filling spike for the Defect Dark plan.
Explosive AmpouleExplosive Ampoule · Tier A10 AoE clears small adds or chips a whole board on a single use.
FortifierFortifier · Tier ATripling your Block can turn a modest defensive turn into a wall against a boss hit.
Ghost in a JarGhost in a Jar · Tier A1 Intangible negates a full turn of damage, a clutch defensive button.
Gigantification PotionGigantification Potion · Tier ATriple damage on your next attack is a massive single-target burst, ideal for executing elites.
Liquid MemoriesLiquid Memories · Tier ARecurring a played key card for free is flexible high-impact value.
Poison PotionPoison Potion · Tier A6 instant Poison jump-starts the Silent's Poison plan or finishes a low enemy.
Potion of BindingPotion of Binding · Tier AMass Weak and Vulnerable both protects you and amplifies an AoE turn.
Potion of CapacityPotion of Capacity · Tier A+2 Orb Slots permanently widens the Defect board mid-combat.
Potion of DoomPotion of Doom · Tier A33 Doom is a huge spike toward a Necrobinder execute.
Powdered DemisePowdered Demise · Tier A9 HP loss per enemy turn is strong recurring damage against slower bosses.
Shackling PotionShackling Potion · Tier AStripping 7 enemy Strength shuts down a hard-hitting attacker for a turn.
Snecko OilSnecko Oil · Tier ADrawing 7 cards is enormous; randomized costs often turn into free big plays.
Soldier's StewSoldier's Stew · Tier AGiving all Strike cards Replay can double an Ironclad's whole attack turn.
Strength PotionStrength Potion · Tier A+2 permanent Strength is a strong scaling spike, especially on a multi-hit attack turn.
Swift PotionSwift Potion · Tier AThree free cards digs to your win condition or refuels a stalled hand.B
Attack Potion
Beetle Juice
Blessing of the Forge
Clarity Extract
Colorless Potion
Cure All
Dexterity Potion
Droplet of Precognition
Focus Potion
Fruit Juice
Fysh Oil
Gambler's Brew
Glowwater Potion
Heart of Iron
King's Courage
Lucky Tonic
Mazaleth's Gift
Orobic Acid
Pot of Ghouls
Potion-Shaped Rock
Power Potion
Radiant Tincture
Ship in a Bottle
Skill Potion
Stable Serum
Touch of Insanity
Vulnerable Potion
Weak Potion
D
Flex PotionFlex Potion · Tier DThe 5 Strength vanishes at end of turn, so it only matters on a single explosive turn — usually too narrow.
Foul PotionFoul Potion · Tier DHitting all players and enemies for 12 is too indiscriminate; usually best just sold to the Merchant.
Speed PotionSpeed Potion · Tier DTemporary Dexterity that disappears at end of turn rarely lines up with enough Block cards to matter.How we grade: These are editorial S–D opinions grounded in card text and the archetypes our builds run — never scraped win-rates. S/A are our hero and core picks, B are flexible includes, C/D are weaker or trap options. Hover a thumbnail for the reasoning.