Updated for Data 2026-05-05· Untapped listing scrapeEarly Access — numbers may shift with patches.

Poison Potion FAQ
- Is Poison Potion good in Slay the Spire 2?
- Poison Potion is a Common potion: Apply 6 Poison. It is most associated with the Silent, but potions drop for any run. Rarer potions tend to swing harder, so weigh the immediate payoff against holding a slot open for an emergency.
- When should I use Poison Potion?
- Drink Poison Potion when its effect — Apply 6 Poison. — directly answers the floor in front of you, such as an elite, boss, or a turn you would otherwise lose tempo. Holding potions for the right moment usually beats spending them on trash fights.
Related potions
- Cunning Potion · Uncommon
- Ghost in a Jar · Rare
- Ashwater · Uncommon
- Attack Potion · Common
- Beetle Juice · Rare
- Blessing of the Forge · Uncommon