Updated for Data 2026-05-05· Untapped listing scrapeEarly Access — numbers may shift with patches.

Powdered Demise
Colorless · Uncommon
Enemy loses 9 HP at the end of each of its turns.
Source: Untapped.gg
Powdered Demise FAQ
- Is Powdered Demise good in Slay the Spire 2?
- Powdered Demise is a Uncommon potion: Enemy loses 9 HP at the end of each of its turns. It is a Colorless potion, so any character can roll or buy it. Rarer potions tend to swing harder, so weigh the immediate payoff against holding a slot open for an emergency.
- When should I use Powdered Demise?
- Drink Powdered Demise when its effect — Enemy loses 9 HP at the end of each of its turns. — directly answers the floor in front of you, such as an elite, boss, or a turn you would otherwise lose tempo. Holding potions for the right moment usually beats spending them on trash fights.
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