Updated for Data 2026-05-05· Untapped listing scrapeEarly Access — numbers may shift with patches.
Potion of Doom FAQ
- Is Potion of Doom good in Slay the Spire 2?
- Potion of Doom is a Common potion: Apply 33 Doom. It is most associated with the Necrobinder, but potions drop for any run. Rarer potions tend to swing harder, so weigh the immediate payoff against holding a slot open for an emergency.
- When should I use Potion of Doom?
- Drink Potion of Doom when its effect — Apply 33 Doom. — directly answers the floor in front of you, such as an elite, boss, or a turn you would otherwise lose tempo. Holding potions for the right moment usually beats spending them on trash fights.
Related potions
- Bone Brew · Uncommon
- Pot of Ghouls · Rare
- Ashwater · Uncommon
- Attack Potion · Common
- Beetle Juice · Rare
- Blessing of the Forge · Uncommon