Should I upgrade Outbreak in Slay the Spire 2?

Compare the upgraded text: Every 3 times you apply Poison, deal 15 damage to ALL enemies.. If the upgrade lowers cost, adds damage/block, or enables a combo piece, it is usually high priority.

What builds use Outbreak?

Outbreak appears in 1 tracked build: Venom Cascade (S-tier, core card).

What character uses Outbreak?

Outbreak is tagged as a Silent card. See the Silent build hub for archetypes that care about it.

Updated for Data 2026-03-17Early Access — numbers may shift with patches.

Outbreak

Silent · Power · Uncommon · 1 cost

Base

Upgraded

Card text

Every 3 times you apply Poison, deal 11 damage to ALL enemies.

Outbreak+

Every 3 times you apply Poison, deal 15 damage to ALL enemies.

Builds that use Outbreak

Archetypes that draft this card in real runs, with the role it plays.

SVenom CascadeSilent · Core card

Keywords

Poison

Build context

See the Silent build hub for archetypes that feature this card in real runs.

Related cards

Outbreak FAQ

Should I upgrade Outbreak in Slay the Spire 2?: Compare the upgraded text: Every 3 times you apply Poison, deal 15 damage to ALL enemies.. If the upgrade lowers cost, adds damage/block, or enables a combo piece, it is usually high priority.
What builds use Outbreak?: Outbreak appears in 1 tracked build: Venom Cascade (S-tier, core card).
What character uses Outbreak?: Outbreak is tagged as a Silent card. See the Silent build hub for archetypes that care about it.

Patch history

SpireForge snapshots card text from Untapped exports dated 2026-03-17. When Mega Crit ships a balance patch, we re-run the scraper and refresh every affected URL—see /patches for the editorial log.