Should I upgrade Envenom in Slay the Spire 2?

Compare the upgraded text: Whenever an Attack deals unblocked damage, apply 2 Poison.. If the upgrade lowers cost, adds damage/block, or enables a combo piece, it is usually high priority.

What builds use Envenom?

Envenom appears in 1 tracked build: Venom Cascade (S-tier, core card).

What character uses Envenom?

Envenom is tagged as a Silent card. See the Silent build hub for archetypes that care about it.

Updated for Data 2026-03-17Early Access — numbers may shift with patches.

Envenom

Silent · Power · Rare · 2 cost

Base

Upgraded

Card text

Whenever an Attack deals unblocked damage, apply 1 Poison.

Envenom+

Whenever an Attack deals unblocked damage, apply 2 Poison.

Builds that use Envenom

Archetypes that draft this card in real runs, with the role it plays.

SVenom CascadeSilent · Core card

Keywords

Poison

Build context

See the Silent build hub for archetypes that feature this card in real runs.

Related cards

Envenom FAQ

Should I upgrade Envenom in Slay the Spire 2?: Compare the upgraded text: Whenever an Attack deals unblocked damage, apply 2 Poison.. If the upgrade lowers cost, adds damage/block, or enables a combo piece, it is usually high priority.
What builds use Envenom?: Envenom appears in 1 tracked build: Venom Cascade (S-tier, core card).
What character uses Envenom?: Envenom is tagged as a Silent card. See the Silent build hub for archetypes that care about it.

Patch history

SpireForge snapshots card text from Untapped exports dated 2026-03-17. When Mega Crit ships a balance patch, we re-run the scraper and refresh every affected URL—see /patches for the editorial log.