Updated for Data 2026-03-17Early Access — numbers may shift with patches.
Synthesis
Defect · Attack · Uncommon · 2 cost
Base

Upgraded

Card text
Deal 12 damage. The next Power you play costs 0 Energy.
Synthesis+
Deal 18 damage. The next Power you play costs 0 Energy.
Builds that use Synthesis
Archetypes that draft this card in real runs, with the role it plays.
Build context
See the Defect build hub for archetypes that feature this card in real runs.
Related cards
Synthesis FAQ
- Should I upgrade Synthesis in Slay the Spire 2?
- Compare the upgraded text: Deal 18 damage. The next Power you play costs 0 Energy.. If the upgrade lowers cost, adds damage/block, or enables a combo piece, it is usually high priority.
- What builds use Synthesis?
- Synthesis appears in 1 tracked build: Machine Mind (B-tier, core card).
- What character uses Synthesis?
- Synthesis is tagged as a Defect card. See the Defect build hub for archetypes that care about it.
Patch history
SpireForge snapshots card text from Untapped exports dated 2026-03-17. When Mega Crit ships a balance patch, we re-run the scraper and refresh every affected URL—see /patches for the editorial log.







