Should I upgrade Poisoned Stab in Slay the Spire 2?

Compare the upgraded text: Deal 8 damage. Apply 4 Poison.. If the upgrade lowers cost, adds damage/block, or enables a combo piece, it is usually high priority.

What builds use Poisoned Stab?

Poisoned Stab appears in 1 tracked build: Venom Cascade (S-tier, flex pick).

What character uses Poisoned Stab?

Poisoned Stab is tagged as a Silent card. See the Silent build hub for archetypes that care about it.

Updated for Data 2026-03-17Early Access — numbers may shift with patches.

Poisoned Stab

Silent · Attack · Common · 1 cost

Base

Upgraded

Card text

Deal 6 damage. Apply 3 Poison.

Poisoned Stab+

Deal 8 damage. Apply 4 Poison.

Builds that use Poisoned Stab

Archetypes that draft this card in real runs, with the role it plays.

SVenom CascadeSilent · Flex pick

Keywords

Poison

Build context

See the Silent build hub for archetypes that feature this card in real runs.

Related cards

Poisoned Stab FAQ

Should I upgrade Poisoned Stab in Slay the Spire 2?: Compare the upgraded text: Deal 8 damage. Apply 4 Poison.. If the upgrade lowers cost, adds damage/block, or enables a combo piece, it is usually high priority.
What builds use Poisoned Stab?: Poisoned Stab appears in 1 tracked build: Venom Cascade (S-tier, flex pick).
What character uses Poisoned Stab?: Poisoned Stab is tagged as a Silent card. See the Silent build hub for archetypes that care about it.

Patch history

SpireForge snapshots card text from Untapped exports dated 2026-03-17. When Mega Crit ships a balance patch, we re-run the scraper and refresh every affected URL—see /patches for the editorial log.