Updated for Data 2026-03-17Early Access — numbers may shift with patches.
Genetic Algorithm
Defect · Skill · Rare · 1 cost
Base
Upgraded
Card text
Gain 1 Block. Permanently increase this card's Block by 3. Exhaust.
Genetic Algorithm+
Gain 1 Block. Permanently increase this card's Block by 4. Exhaust.
Keywords
Build context
See the Defect build hub for archetypes that feature this card in real runs.
Related cards
Genetic Algorithm FAQ
- Should I upgrade Genetic Algorithm in Slay the Spire 2?
- Compare the upgraded text: Gain 1 Block. Permanently increase this card's Block by 4. Exhaust.. If the upgrade lowers cost, adds damage/block, or enables a combo piece, it is usually high priority.
- What builds use Genetic Algorithm?
- Genetic Algorithm is tagged as a Defect card. See the Defect build hub for archetypes that care about it.
- What character uses Genetic Algorithm?
- Genetic Algorithm is tagged as a Defect card. See the Defect build hub for archetypes that care about it.
Patch history
SpireForge snapshots card text from Untapped exports dated 2026-03-17. When Mega Crit ships a balance patch, we re-run the scraper and refresh every affected URL—see /patches for the editorial log.