Should I upgrade Bubble Bubble in Slay the Spire 2?

Compare the upgraded text: If the enemy has Poison, apply 12 Poison.. If the upgrade lowers cost, adds damage/block, or enables a combo piece, it is usually high priority.

What builds use Bubble Bubble?

Bubble Bubble appears in 1 tracked build: Venom Cascade (S-tier, core card).

What character uses Bubble Bubble?

Bubble Bubble is tagged as a Silent card. See the Silent build hub for archetypes that care about it.

Updated for Data 2026-03-17Early Access — numbers may shift with patches.

Bubble Bubble

Silent · Skill · Uncommon · 1 cost

Base

Upgraded

Card text

If the enemy has Poison, apply 9 Poison.

Bubble Bubble+

If the enemy has Poison, apply 12 Poison.

Builds that use Bubble Bubble

Archetypes that draft this card in real runs, with the role it plays.

SVenom CascadeSilent · Core card

Keywords

Poison

Build context

See the Silent build hub for archetypes that feature this card in real runs.

Related cards

Bubble Bubble FAQ

Should I upgrade Bubble Bubble in Slay the Spire 2?: Compare the upgraded text: If the enemy has Poison, apply 12 Poison.. If the upgrade lowers cost, adds damage/block, or enables a combo piece, it is usually high priority.
What builds use Bubble Bubble?: Bubble Bubble appears in 1 tracked build: Venom Cascade (S-tier, core card).
What character uses Bubble Bubble?: Bubble Bubble is tagged as a Silent card. See the Silent build hub for archetypes that care about it.

Patch history

SpireForge snapshots card text from Untapped exports dated 2026-03-17. When Mega Crit ships a balance patch, we re-run the scraper and refresh every affected URL—see /patches for the editorial log.