Updated for Data 2026-03-17Early Access — numbers may shift with patches.
Infection
Colorless · Status · Status · 0 cost
Base
Upgraded
Card text
Unplayable. At the end of your turn, if this is in your Hand, take 3 damage.
Infection
Unplayable. At the end of your turn, if this is in your Hand, take 3 damage.
Keywords
Build context
Colorless cards splash into every class. Browse the Colorless card pool and pair it with any class build hub for archetypes that want it.
Related cards
Infection FAQ
- Should I upgrade Infection in Slay the Spire 2?
- Compare the upgraded text: Unplayable. At the end of your turn, if this is in your Hand, take 3 damage.. If the upgrade lowers cost, adds damage/block, or enables a combo piece, it is usually high priority.
- What builds use Infection?
- Infection is tagged as a Colorless card. Colorless cards can be picked by any class.
- What character uses Infection?
- Infection is tagged as a Colorless card. Colorless cards can be picked by any class.
Patch history
SpireForge snapshots card text from Untapped exports dated 2026-03-17. When Mega Crit ships a balance patch, we re-run the scraper and refresh every affected URL—see /patches for the editorial log.